Gestational Age, Infant Birth Weight, and Subsequent Risk of Type 2 Diabetes in Mothers: Nurses’ Health Study II

نویسندگان

  • Tamarra M. James-Todd
  • S. Ananth Karumanchi
  • Eileen L. Hibert
  • Susan M. Mason
  • Mary A. Vadnais
  • Frank B. Hu
  • Janet W. Rich-Edwards
چکیده

INTRODUCTION Women with a history of gestational diabetes mellitus (GDM) are at higher risk of developing type 2 diabetes (T2DM); however, little is known about the association between other common pregnancy complications (eg, preterm birth, macrosomia) and T2DM risk. We examined the associations between first-pregnancy preterm, postterm birth, low birth weight, and macrosomia with subsequent risk of T2DM. METHODS We conducted a prospective cohort study of Nurses' Health Study II (NHSII) participants; 51,728 women in the study had a single live birth and complete pregnancy history. NHSII confirmed incident diabetes mellitus through supplemental questionnaires. Participants were followed from year of first birth until 2005. We defined gestational age as very preterm (20 to ≤32 weeks), moderate preterm (33 to ≤37 weeks), term (38 to ≤42 weeks), and postterm (≥43 weeks). We defined low birth weight as an infant born at term weighing less than 5.5 pounds, and we defined macrosomia as an infant born at term weighing 10 pounds or more. We used Cox proportional hazards models, adjusting for potential confounders. RESULTS Women with a very preterm birth (2%) had an increased T2DM risk (adjusted hazard ratio, 1.34; 95% confidence interval [CI], 1.05-1.71). This increased risk emerged in the decade following pregnancy. Macrosomia (1.5%) was associated with a 1.61 increased T2DM risk, after adjusting for risk factors, including GDM (95% CI, 1.24-2.08). This association was apparent within the first 5 years after pregnancy. Moderate preterm and term low birth weight did not significantly increase the risk of T2DM over the 35-year follow-up time. CONCLUSION Women who experienced a very preterm birth or had an infant that weighed 10 pounds or more may benefit from lifestyle intervention to reduce T2DM risk. If replicated, these findings could lead to a reduced risk of T2DM through improved primary care for women experiencing a preterm birth or an infant of nonnormal birth weight.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Prediction Value of CRIB-II in Outcome of Preterm and Low Birth Weight Infants: a Prospective Cohort Study

Background: One of the most common methods of identifying mortality risk is the Clinical Risk Index for Babies scoring system (CRIB- II). The aim of this study was assessing the value of CRIB- II in predicting mortality risk in preterm and low birth weight infants in East Azerbaijan- Iran. Materials and Methods: This prospective cohort study was carried out in 2013-2014 during 6 months in NICUs...

متن کامل

Assessment of Risk Factors for Low Birth weight of Infants in Zanjan Province Using Quantile Regression Analysis

Background: Low birth weight is one of the key indicators to assess the health of infants, and appropriate birth weight is one of the most important goals of any health system which also reflects the quality of prenatal care. Objectives: The present research aimed to study some of the factors associated with low birth weight using quantile regression analysis. Methods: A cross-sectional s...

متن کامل

Cord Serum Lipid Profile of Infants of Diabetic Mothers

Background: Infants of diabetic mothers (IDM) is a critical issue in pediatrics, which is regarded as a major risk factor for birth trauma, respiratory distress syndrome (RDS), birth asphyxia, transient tachypnea of the newborn (TTN) and jaundice. IDM is also a risk factor for microvascular (e.g., ocular and renal complications) and macrovascular complications (e.g., cerebrovascular accident, a...

متن کامل

Assessment of the Relationship between Recurrent High-risk Pregnancy and Mothers’ Previous Experience of Having an Infant Admitted to a Neonatal Intensive Care Unit

Background & aim:  High-risk pregnancies increase the risk of Intensive Care Unit (ICU) and Neonatal Intensive Care Unit (NICU) admission in mothers and their newborns. In this study, we aimed to identify the association between the recurrence of high-risk pregnancy and mothers’ previous experience of having an infant admitted to NICU. Methods:We performed a cohort, retrospective study to compa...

متن کامل

Importance of familial factors in associations between offspring birth weight and parental risk of type-2 diabetes.

BACKGROUND It is hypothesized that associations found between birth weight and subsequent risk of type-2 diabetes are due to inherited genes affecting both fetal growth and metabolism of insulin. METHODS To study whether there is a familial (shared environmental and genetic) link between birth weight and type-2 diabetes, the authors used a sample of 11,411 Swedish like-sexed twins born from 1...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2013